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Primary hepatic lymphoma after lung transplantation: a report of 2 cases
- Source :
- Transplantation Proceedings, Transplantation Proceedings, 2021, 53 (2), pp.692-695. ⟨10.1016/j.transproceed.2021.01.030⟩
- Publication Year :
- 2021
- Publisher :
- ELSEVIER SCIENCE INC, 2021.
-
Abstract
- International audience; Background. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non -Hodgkin lymphoma in the posttransplant setting. Treatment is based on chemotherapy; surgery is still debated and should be performed in very select cases. Methods. We observed 2 patients out of 300 who underwent lung transplantation in the Nouvel Hopital Civil between 2013 and 2019 with primary hepatic lymphoma. Chemotherapy with a rituximab-cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone protocol was performed in all patients. Mycophenolate mofetil was interrupted before treatment, and everolimus was introduced after chemotherapy by associating tacrolimus withdrawal. Results. One patient showed complete remission; after 7 years, no recurrence has been noticed. The second is still undergoing chemotherapy with no signs of disease progression. Conclusions. DLBCL risk is higher in solid organ transplant recipients than in the general population. Primary hepatic lymphoma diagnosis is often difficult and based on histologic findings after initial clinical and radiological suspicion of primary or secondary liver neoplasia. Diagnosis is challenging because no clinical, radiological, or biological features exist. Biopsy is always indicated for histologic confirmation. Chemotherapy is the mainstay of therapy, but surgery may be indicated in very select patients.
- Subjects :
- remission induction
Vincristine
medicine.medical_specialty
diffuse
medicine.medical_treatment
Population
lymphoma
male
immune system diseases
Prednisone
hemic and lymphatic diseases
medicine
lung transplantation
Lung transplantation
education
humans
immunocompromised host
Transplantation
education.field_of_study
Chemotherapy
Everolimus
liver neoplasms
business.industry
adult
medicine.disease
Tacrolimus
Lymphoma
aged
Surgery
Lymphoma, Large B-Cell, Diffuse
Radiology
large B-Cell
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00411345
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings, Transplantation Proceedings, 2021, 53 (2), pp.692-695. ⟨10.1016/j.transproceed.2021.01.030⟩
- Accession number :
- edsair.doi.dedup.....955fd1790a3a03d01471045b2bca7021