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Continuous vagal nerve stimulation affects atrial neural remodeling and reduces atrial fibrillation inducibility in rabbits
- Source :
- Cardiovascular Pathology. 24:395-398
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- The effects of continuous vagal nerve stimulation (VNS) on atrial neural remodeling during atrial fibrillation (AF) remain unclear.To test the hypothesis that VNS affects atrial neural remodeling and reduces AF inducibility.Twenty rabbits were randomly divided into two groups: rapid atrial pacing (RAP) group and RAP with VNS group. AF inducibility studies and atrial histologic analyses were performed after 4 weeks.Five rabbits of RAP group (5/10) in the RAP group developed sustained AF. None of rabbits in RAP with VNS group had developed AF. The incidence of sustained AF in VNS group was significant lower than that in rapid pacing group (P.01). Treatment with VNS resulted in a significant reduction in atrial neural remodeling and AF duration (P.01).Atrial neural remodeling plays an important role in the initiation and maintenance of AF. Modulating autonomic nerve function with VNS can contribute to AF control.
- Subjects :
- Male
medicine.medical_specialty
Sympathetic Nervous System
Time Factors
Tyrosine 3-Monooxygenase
Vagus Nerve Stimulation
Vagal nerve
Stimulation
Pathology and Forensic Medicine
Rapid pacing
GAP-43 Protein
Internal medicine
Atrial Fibrillation
medicine
Animals
Heart Atria
Autonomic nerve
Atrial pacing
business.industry
fungi
Cardiac Pacing, Artificial
Vagus Nerve
Atrial fibrillation
Atrial Remodeling
General Medicine
medicine.disease
Disease Models, Animal
Cardiology
Female
Rabbits
sense organs
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 10548807
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Pathology
- Accession number :
- edsair.doi.dedup.....957558bc8933374cf8fb200aa63744cd