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An N-N linked dimeric indole alkaloid from the marine sponge-associated rare actinomycetes Kocuria sp. S42
- Publication Year :
- 2022
- Publisher :
- Taylor & Francis, 2022.
-
Abstract
- Marine derived rare actinomycetes is emerging as one of the new sources for various natural products for further drug discovery. Dimeric indole alkaloids represent a group of structurally diverse natural products and N-N linkage is a special dimerization mode. Here, we report the isolation of 1,1'-([1,1'-biindole]-3,3'-diyl) bis (ethane-1,2-diol), a new tryptophan-derived indole alkaloid from the marine sponge-derived Kocuria sp. S42. The structure was established based on extensive spectroscopic analyses, including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass (HR-ESI-MS) spectrometry. The new dimeric indole alkaloid via N-N linkage exhibits moderate antimicrobial activity.
- Subjects :
- Organic Chemistry
Plant Science
Biochemistry
Analytical Chemistry
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....957628bcd395ac41f5ec04ee7a0c358e
- Full Text :
- https://doi.org/10.6084/m9.figshare.20315035