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5-HT 2C receptors in the ventral tegmental area, but not in the arcuate nucleus, mediate the hypophagic and hypolocomotor effects of the selective 5-HT 2C receptor agonist AR231630 in rats
- Source :
- Behavioural Brain Research, Behavioural Brain Research, Elsevier, 2018, 347, pp.234-241. ⟨10.1016/j.bbr.2018.03.006⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- Central serotonin systems have long been associated with the control of feeding behavior and the modulation of behavioral effects of psychostimulants. 5-HT2C receptors are present in hypothalamic centers such as the arcuate nucleus (ARC), controlling homeostatic regulation of food intake, as well as in the ventral tegmental area (VTA), a region involved in motivation aspects in multiple behaviors, including feeding. In the present study, we investigated whether the 5-HT2C receptors control amphetamine-evoked locomotor activity and regulate food consumption. Localized microinjections into the VTA or the ARC were used to assess the effects of a highly selective 5-HT2C receptor agonist, AR231630, on the locomotor stimulant effect of amphetamine as well as on food intake. AR231630 injected into the VTA, but not into the ARC, dose-dependently reduced locomotor activity elicited by amphetamine. Unexpectedly, intra-ARC injection of AR231630 did not reduce food intake even at the dose of 10 μg, whereas intra-VTA injection of the same dose of AR231630 did. In addition, we showed that pretreatment with the selective 5-HT2C receptor antagonist SB242084 infused into the VTA partially prevented hypophagia induced by peripheral administration of AR231630. We can conclude that 5-HT2C receptor in the VTA, but not in the ARC, participates in both homeostatic and hedonic food intake and brain reward function.
- Subjects :
- 0301 basic medicine
Agonist
Locomotor activity
medicine.medical_specialty
medicine.drug_class
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Reward
Food intake
Internal medicine
medicine
Behavioral pharmacology
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Amphetamine
ComputingMilieux_MISCELLANEOUS
Arc (protein)
Chemistry
musculoskeletal, neural, and ocular physiology
Receptor antagonist
Ventral tegmental area
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Brain stimulation reward
Serotonin
5-HT2C receptor agonist
030217 neurology & neurosurgery
medicine.drug
5-HT2C agonist
Subjects
Details
- Language :
- English
- ISSN :
- 01664328 and 18727549
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research, Behavioural Brain Research, Elsevier, 2018, 347, pp.234-241. ⟨10.1016/j.bbr.2018.03.006⟩
- Accession number :
- edsair.doi.dedup.....959562d1897fde580cebde94a5a1ce4d