Back to Search
Start Over
Immunosuppression as a Hallmark of Critical COVID-19: Prospective Study
- Source :
- Cells, Volume 10, Issue 6, Cells, Vol 10, Iss 1293, p 1293 (2021)
- Publication Year :
- 2021
-
Abstract
- The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an impact on the course of COVID-19, and play a role in the clinical outcome of the disease. Here, we performed a comprehensive analysis of peripheral blood lymphocyte subpopulations in 82 patients with COVID-19, including 31 patients with a critical course of the disease. In COVID-19 patients who required hospitalization we analyzed T cell subsets, including Treg cells, as well as TCRα/β and γ/δ, NK cells, and B cells, during the first two weeks after admission to hospital due to the SARS-CoV-2 infection, with marked reductions in leukocytes subpopulations, especially in critically ill COVID-19 patients. We showed decreased levels of Th, Ts cells, Treg cells (both naïve and induced), TCRα/β and γ/δ cells, as well as CD16+CD56+NK cells in ICU compared to non-ICU COVID-19 patients. We observed impaired function of T and NK cells in critically ill COVID-19 patients with extremely low levels of secreted cytokines. We found that the IL-2/INFγ ratio was the strongest indicator of a critical course of COVID-19, and was associated with fatal outcomes. Our findings showed markedly impaired innate and adaptive responses in critically ill COVID-19 patients, and suggest that the immunosuppressive state in the case of a critical course of SARS-CoV-2 infection might reflect subsequent clinical deterioration and predict a fatal outcome.
- Subjects :
- Male
QH301-705.5
T cell
medicine.medical_treatment
Critical Illness
T cells
NK cells
CD16
Adaptive Immunity
Risk Assessment
Severity of Illness Index
Article
regulatory T cells
Immune tolerance
Leukocyte Count
IL-2/INFγ ratio
medicine
Immune Tolerance
TNFα
Humans
Hospital Mortality
Prospective Studies
Biology (General)
Prospective cohort study
Aged
immunosuppression
lymphocyte subsets
Clinical Deterioration
business.industry
SARS-CoV-2
IL-2
COVID-19
Immunosuppression
General Medicine
Middle Aged
TCRα/β
Acquired immune system
Immunity, Innate
INFγ
Hospitalization
medicine.anatomical_structure
Peripheral blood lymphocyte
Immunology
Tumor necrosis factor alpha
Female
Poland
TCR γ/δ cells
business
Subjects
Details
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....95aaf65e5e7f86de4b782125a01e4877