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The βc receptor family - Structural insights and their functional implications
- Source :
- Cytokine. 74(2)
- Publication Year :
- 2015
-
Abstract
- Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc). These cytokines regulate the growth, differentiation, migration and effector function activities of many hematopoietic cells in bone marrow, blood and sites of inflammation. Excessive or aberrant signaling can result in chronic inflammatory conditions and myeloid leukemias. The crystal structures of the GM-CSF ternary complex, the IL-5 binary complex and the very recent IL-3 receptor alpha subunit build upon decades of structure-function studies, giving new insights into cytokine-receptor specificity and signal transduction. Selective modulation of receptor function is now a real possibility and the structures of the βc receptor family are being used to discover novel and disease-specific therapeutics. Refereed/Peer-reviewed
- Subjects :
- Immunology
Interleukin 5 receptor alpha subunit
granulocyte-macrophage colony stimulating factor
Interleukin-17 receptor
Biology
Biochemistry
Interleukin 10 receptor, alpha subunit
Cytokine Receptor Common beta Subunit
Structure-Activity Relationship
Immunology and Allergy
Animals
Humans
Protein Structure, Quaternary
Molecular Biology
Interleukin 12 receptor, beta 1 subunit
Common gamma chain
Genetics
GM-CSF Receptor
beta common receptor
Hematology
Cell biology
inflammation
Interleukin-21 receptor
interleukin-3
Cytokines
interleukin-5
Signal Transduction
Subjects
Details
- ISSN :
- 10960023
- Volume :
- 74
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cytokine
- Accession number :
- edsair.doi.dedup.....95ae1a6739735d90d9b407a4aa59bd4e