Pulmonary haemodynamic effects of interatrial shunt in heart failure with preserved ejection fraction: a preclinical study

Authors :: Jean-Baptiste Michel
Pichoy Danial
Brigitte Escoubet
Sébastien Dupont
Guillaume Jondeau
Mary Osborne-Pellegrin
Source :: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 16(5)
Publication Year :: 2019
Abstract: AIMS The aim of this study was to evaluate the effect of the creation of a left-to-right interatrial shunt on pulmonary haemodynamics in rats with heart failure with preserved ejection fraction (HFPEF). METHODS AND RESULTS An interatrial communication (IAC) was created in 11 healthy rats (Lewis rats) and 11 rats which developed HFPEF (36-week-old spontaneously hypertensive rats [SHR]). Effects of the interatrial shunt were compared to 11 sham-operated Lewis and 11 sham-operated SHR. At 45 days post shunt, strain effect was observed in diastolic function (E/A ratio, p

ISSN :: 19696213
Volume :: 16
Issue :: 5
Database :: OpenAIRE
Journal :: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Accession number :: edsair.doi.dedup.....95c32960e3c0569e93ebff3f5fbe7fdd

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