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DISCUSSION PAPER: LOSS OF CELLULAR ANTIGENS DURING MALIGNANT TRANSFORMATION
- Source :
- Annals of the New York Academy of Sciences. 276:243-253
- Publication Year :
- 1976
- Publisher :
- Wiley, 1976.
-
Abstract
- Normal human diploid cells, such as WE-38, transformed by an oncogenic virus, SV40, are greatly depleted of a cathodal esterase isozyme using both immunological and enzymatic criteria. This cathodal esterase is primate-specific and associated with lysosomes of many different tissue cells. It provides a clear example of antigenic loss associated with malignant change.
- Subjects :
- Simian virus 40
Hybrid Cells
Biology
Esterase
Isozyme
General Biochemistry, Genetics and Molecular Biology
Cell Line
Malignant transformation
Species Specificity
History and Philosophy of Science
Antigen
Isoelectric Point
Antigens
chemistry.chemical_classification
L-Lactate Dehydrogenase
General Neuroscience
Esterases
Molecular biology
WI-38
Isoenzymes
Cell Transformation, Neoplastic
Enzyme
chemistry
Cellular antigens
Polyomavirus
Oncovirus
Subjects
Details
- ISSN :
- 17496632 and 00778923
- Volume :
- 276
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences
- Accession number :
- edsair.doi.dedup.....95caead6ed7cec67dfc8d149ad736b19