Multicharged Supramolecular Assembly Mediated by Polycationic Cyclodextrin for Efficiently Photodynamic Antibacteria

Supramolecular antimicrobial materials based on synthetic macrocycles have recently aroused enormous interests due to their controllable and effective antibacterial treatment. Herein, a multicharged supramolecular assembly was fabricated employing the moderate host-guest interaction between hexa-adamantane-appended ruthenium polypyridyl (Ru2) and polycationic cyclodextrin (CD-QAS) in water. The positively multicharged feature of supramolecular assembly could remarkably enhance the specific intercalation and accumulation in negatively charged bacteria membrane leading to the physical membrane damage. Subsequently, the assembly could efficiently initiate the significant generation of singlet oxygen (