Back to Search
Start Over
Differential Prognostic Value of Metabolic Heterogeneity of Primary Tumor and Metastatic Lymph Nodes in Patients with Pharyngeal Cancer
- Source :
- Anticancer Research. 37
- Publication Year :
- 2017
- Publisher :
- Anticancer Research USA Inc., 2017.
-
Abstract
- BACKGROUND/AIM We aimed to explore the prognostic value of metabolic heterogeneity of 18F-FDG uptake in chemoradiotherapy-treated pharyngeal cancer patients. PATIENTS AND METHODS This study included 52 consecutive patients with pharyngeal cancer who underwent 18F-FDG PET/CT before definitive chemoradiotherapy. The heterogeneity factor (HF) was defined as the derivative (dV/dT) of a volume-threshold function for primary tumors and metastatic lymph nodes. The relationships between clinical parameters and HFs of primary tumors (pHF) and metastatic lymph nodes (nHF) were analyzed. RESULTS The pHF (range=∓1.367 - -0.027; median=-0.152) was significantly correlated with the maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis. Induction chemotherapy response was not correlated with HF, whereas response to radiotherapy was significantly better in patients with high pHF (low heterogeneity). Consistently, the 2-year locoregional recurrence-free survival was significantly better in patients with high pHF (82.9% for pHF>-0.152 vs. 30.5% for pHF
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Standardized uptake value
Kaplan-Meier Estimate
Disease-Free Survival
030218 nuclear medicine & medical imaging
Young Adult
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Predictive Value of Tests
Positron Emission Tomography Computed Tomography
Internal medicine
Pharyngeal cancer
mental disorders
Humans
Medicine
Aged
Aged, 80 and over
Squamous Cell Carcinoma of Head and Neck
business.industry
Metabolic heterogeneity
Induction chemotherapy
Pharyngeal Neoplasms
Chemoradiotherapy
Middle Aged
medicine.disease
Primary tumor
Radiation therapy
Treatment Outcome
Head and Neck Neoplasms
Lymphatic Metastasis
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Female
Lymph Nodes
Lymph
Radiopharmaceuticals
business
Glycolysis
Subjects
Details
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....96097a3b6267b602077f3d155bb02c8b