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A role for a pre-T-cell receptor in T-cell development
- Source :
- Immunology Today. 14:610-614
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Expression of a productive T-cell receptor (TCR) beta gene has profound consequences for T-cell development, preceding an increase in thymocyte number, appearance of CD4 and CD8 coreceptors and suppression of further TCR beta-gene rearrangement. Here Marcus Groettrup and Harald von Boehmer discuss the data obtained in various experimental models and describe a novel signal transducing receptor complex on pre-T cells, which may regulate the TCR beta-induced developmental changes.
- Subjects :
- CD4-Positive T-Lymphocytes
Receptor complex
Receptors, Antigen, T-Cell, alpha-beta
Stem Cells
T cell
Immunology
T-cell receptor
Mice, Transgenic
Mice, SCID
T lymphocyte
Biology
T-Lymphocytes, Regulatory
Cell biology
Mice
Thymocyte
medicine.anatomical_structure
medicine
Animals
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Signal transduction
Receptor
CD8
Signal Transduction
Subjects
Details
- ISSN :
- 01675699
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Immunology Today
- Accession number :
- edsair.doi.dedup.....960b2cedd3c66fc3865af78c1386e7e6