Back to Search
Start Over
The Effects of Growth Hormone Treatment on Health-Related Quality of Life in Children
- Source :
- Hormone Research in Paediatrics. 65:243-249
- Publication Year :
- 2006
- Publisher :
- S. Karger AG, 2006.
-
Abstract
- Background/Aims: The effects of growth hormone deficiency (GHD) on linear growth in children are well documented, but there is less convincing evidence regarding the impact on health-related quality of life (QOL). We examined QOL in children aged 8–16 years with acquired GHD following treatment for malignancy (AGHD) or idiopathic GHD (IGHD) on commencing growth hormone treatment (GHT) over 6 months. We adopted a longitudinal design involving consecutive patients and their families attending clinic over an 18-month period. Mothers and children were invited to complete questionnaires before GHT (T1) and 6 months later (T2). Methods: Mothers of 22 children (AGHD n = 14; IGHD n = 8) completed standardized measures of child QOL and behaviour. Children completed parallel measures of QOL, short-term memory tasks and fitness either in clinic or at the family home. Results: For children with AGHD, QOL was significantly below population norms at T1 and improved over time. For children diagnosed with IGHD, QOL at T1 was below, but comparable with population norms. QOL improved over time, though not significantly. Conclusion: GHT is potentially valuable for improving QOL in children, especially in cases of AGHD. We conclude that benefits of GHT for QOL need to be evaluated independent of different diagnostic groups.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Adolescent
Hormone Replacement Therapy
Endocrinology, Diabetes and Metabolism
Population
MEDLINE
Growth hormone deficiency
Endocrinology
Quality of life
Surveys and Questionnaires
medicine
Health Status Indicators
Humans
Child
education
Growth Disorders
Health related quality of life
education.field_of_study
Human Growth Hormone
business.industry
medicine.disease
Recombinant Proteins
humanities
Leukemia, Lymphoid
Growth hormone treatment
Transgender hormone therapy
Pediatrics, Perinatology and Child Health
Quality of Life
Physical therapy
Body Constitution
IGHD
Female
business
Subjects
Details
- ISSN :
- 16632826 and 16632818
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Hormone Research in Paediatrics
- Accession number :
- edsair.doi.dedup.....9611de2cc7b23e39399f3cf5e40b5dfd