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Mucins and associated glycan signatures in colon adenoma–carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

Authors :
Shiv Ram Krishn
Shailendra K. Gautam
Wing-Cheong Lo
Upender Manne
Surinder K. Batra
Lynette M. Smith
Maneesh Jain
Michael A. Hollingsworth
Henrik Clausen
Sonny L. Johansson
Sukhwinder Kaur
Ulla Mandel
Asish Patel
Wai-Tong Louis Fan
Source :
Cancer Letters. 374:304-314
Publication Year :
2016
Publisher :
Elsevier BV, 2016.

Abstract

Development of biomarkers that detect early stage resectable premalignant lesions of colon can provide critical aid in the prevention of colorectal cancer. Recent lines of evidence suggest the utility of mucin expression to predict malignant transformation of colon pre-neoplastic lesions. In this study, we investigated the combined expression of multiple mucins and mucin-associated glycans during the adenoma-carcinoma sequence of colon cancer progression. Further, we evaluated their applicability as markers for differentiating adenomas/adenocarcinomas from hyperplastic polyps. Immunohistochemical analyses performed on colon disease tissue microarrays revealed downregulation of MUC2 and MUC4 expression (p

Details

ISSN :
03043835
Volume :
374
Database :
OpenAIRE
Journal :
Cancer Letters
Accession number :
edsair.doi.dedup.....9619493576b5d2b104aaa20be3938ab0
Full Text :
https://doi.org/10.1016/j.canlet.2016.02.016