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Effect of ethnicity and socioeconomic variation to the gut microbiota composition among pre-adolescent in Malaysia
- Source :
- Scientific Reports
- Publication Year :
- 2015
-
Abstract
- Gut microbiota plays an important role in mammalian host metabolism and physiological functions. The functions are particularly important in young children where rapid mental and physical developments are taking place. Nevertheless, little is known about the gut microbiome and the factors that contribute to microbial variation in the gut of South East Asian children. Here, we compared the gut bacterial richness and composition of pre-adolescence in Northern Malaysia. Our subjects covered three distinct ethnic groups with relatively narrow range of socioeconomic discrepancy. These included the Malays (n = 24), Chinese (n = 17) and the Orang Asli (indigenous) (n = 20). Our results suggested a strong ethnicity and socioeconomic-linked bacterial diversity. Highest bacterial diversity was detected from the economically deprived indigenous children while the lowest diversity was recorded from the relatively wealthy Chinese children. In addition, predicted functional metagenome profiling suggested an over-representation of pathways pertinent to bacterial colonisation and chemotaxis in the former while the latter exhibited enriched gene pathways related to sugar metabolism.
- Subjects :
- Male
Adolescent
Ethnic group
Biodiversity
Zoology
Gut flora
DNA, Ribosomal
Indigenous
Article
Feces
Ethnicity
Humans
Child
Socioeconomic status
Phylogeny
Principal Component Analysis
Multidisciplinary
biology
Ecology
Gastrointestinal Microbiome
Malaysia
High-Throughput Nucleotide Sequencing
Hygiene
biology.organism_classification
Socioeconomic Factors
Metagenomics
Linear Models
Female
Polymorphism, Restriction Fragment Length
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....9636ebd7d0a337a7d3a7c06d4d3a8264