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Impaired long contact white matter fibers integrity is related to depression in Parkinson's disease
- Source :
- CNS Neuroscience & Therapeutics. 24:108-114
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Aims Depression is one of the most common nonmotor symptoms in Parkinson's disease (PD). But the pathogenesis is still unclear. Studies have shown that depression in PD is closely related to the white matter abnormalities, but the number of studies is still very small and lack of whole brain white matter lesions study. Methods In this study, we investigated whole brain white matter integrity in 31 depressed PD patients and 37 nondepressed PD patients by diffusion tensor imaging. Results There was no difference in age, gender, age of onset, disease duration, Hoehn-Yahr scale, Unified Parkinson's Disease Rating Scale scores-III, and Mini-Mental State Examination scores between the two groups. The only difference was the Hamilton Depression Rating Scale. Depressed PD patients showed reduced fractional anisotropy values in the left anterior corona radiata, left posterior thalamic radiation, left cingulum, left superior longitudinal fasciculus, left sagittal stratum (including inferior longitudinal fasciculus and inferior fronto-occipital fasciculus), and left uncinate fasciculus. In patients with depression, the Hamilton Depression Rating Scale (HDRS) was negatively correlated with the FA value in the left cingulum (r = -0.712, P = .032) and left superior longitudinal fasciculus (r = -0.699, P = .025). Conclusions This study suggested depression in PD was related to impaired white matter integrity especially the long contact fibers in the left hemisphere. These findings may be helpful for further understanding the potential mechanisms underlying depression in PD.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Parkinson's disease
behavioral disciplines and activities
Lateralization of brain function
White matter
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Internal medicine
Fasciculus
Fractional anisotropy
medicine
Humans
Cingulum (brain)
Pharmacology (medical)
Inferior longitudinal fasciculus
Depression (differential diagnoses)
Pharmacology
biology
Depression
business.industry
Brain
Parkinson Disease
Original Articles
Middle Aged
biology.organism_classification
medicine.disease
White Matter
Psychiatry and Mental health
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
030104 developmental biology
medicine.anatomical_structure
Cardiology
Female
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17555930
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- CNS Neuroscience & Therapeutics
- Accession number :
- edsair.doi.dedup.....96393770c531aa6ebc2a7e50dc8510b8