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Does Serum Urate Change as Parkinson’s Disease Progresses?

Authors :
Xiqun Chen
Rachit Bakshi
Eric A. Macklin
Yasemin G Hasimoglu
Michael A. Schwarzschild
Source :
Journal of Parkinson's Disease
Publication Year :
2020
Publisher :
IOS Press, 2020.

Abstract

Higher serum urate concentration is associated with decreased risk of Parkinson’s disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disease progression assessed by MDS-UPDRS Part III score, Hoehn and Yahr stage, or DaTscan imaging. Average serum urate concentration was stable over time and change in serum urate concentration did not correlate with worsening of measures of PD progression. These results suggest that serum urate concentration is not a monitoring biomarker of PD progression in early stages.

Details

ISSN :
1877718X and 18777171
Volume :
10
Database :
OpenAIRE
Journal :
Journal of Parkinson's Disease
Accession number :
edsair.doi.dedup.....9651e6176b50b2b64d0f9719cdd69e31
Full Text :
https://doi.org/10.3233/jpd-202064