Back to Search
Start Over
Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking
- Source :
- World journal of gastroenterology. 12(28)
- Publication Year :
- 2006
-
Abstract
- AIM: To investigate whether a fuzzy logic model could predict colorectal cancer (CRC) risk engendered by smoking in hereditary non-polyposis colorectal cancer (HNPCC) patients. METHODS: Three hundred and forty HNPCC mismatch repair (MMR) mutation carriers from the Creighton University Hereditary Cancer Institute Registry were selected for modeling. Age-dependent curves were generated to elucidate the joint effects between gene mutation (hMLH1 or hMSH2), gender, and smoking status on the probability of developing CRC. RESULTS: Smoking significantly increased CRC risk in male hMSH2 mutation carriers (P < 0.05). hMLH1 mutations augmented CRC risk relative to hMSH2 mutation carriers for males (P < 0.05). Males had a significantly higher risk of CRC than females for hMLH1 non smokers (P < 0.05), hMLH1 smokers (P < 0.1) and hMSH2 smokers (P < 0.1). Smoking promoted CRC in a dose-dependent manner in hMSH2 in males (P < 0.05). Females with hMSH2 mutations and both sexes with the hMLH1 groups only demonstrated a smoking effect after an extensive smoking history (P < 0.05). CONCLUSION: CRC promotion by smoking in HNPCC patients is dependent on gene mutation, gender and age. These data demonstrate that fuzzy modeling may enable formulation of clinical risk scores, thereby allowing individualization of CRC prevention strategies.
- Subjects :
- Oncology
Adult
Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Colorectal cancer
DNA Mutational Analysis
Gene mutation
Risk Assessment
Sex Factors
Fuzzy Logic
Predictive Value of Tests
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
neoplasms
Adaptor Proteins, Signal Transducing
Aged
Aged, 80 and over
Colorectal Cancer
business.industry
Smoking
Gastroenterology
Age Factors
nutritional and metabolic diseases
Nuclear Proteins
General Medicine
Middle Aged
medicine.disease
Prognosis
Colorectal Neoplasms, Hereditary Nonpolyposis
Lynch syndrome
digestive system diseases
Surgery
MutS Homolog 2 Protein
Predictive value of tests
Mutation (genetic algorithm)
Colonic Neoplasms
Mutation
Smoking status
DNA mismatch repair
Female
Risk assessment
business
Carrier Proteins
MutL Protein Homolog 1
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 12
- Issue :
- 28
- Database :
- OpenAIRE
- Journal :
- World journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....9663e2b6713d3b66faf81ba2b86d2479