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Is male factor infertility associated with midlife low-grade inflammation? A population based study
- Source :
- Human Fertility. 21:146-154
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Male factor infertility is associated with an increased risk of disease and mortality, which has been related to markers of chronic systemic inflammation. The objective of this study was to investigate the association between male factor infertility and low-grade inflammation and furthermore to examine the lifetime prevalence of male factor infertility and overall infertility (also including female and couple infertility). The study population consisted of 2140 members of the Metropolit 1953 Danish Male Birth Cohort who had participated in the Copenhagen Aging and Midlife Biobank data collection in 2009-2011. Information on male factor infertility and overall infertility was obtained from a questionnaire, and low-grade inflammation was evaluated as the highest plasma levels of C-reactive protein, interleukin-6 and tumour necrosis factor-alpha in the population. The level of interleukin-6 was significantly higher among men with male factor infertility compared with other men adjusted for potential confounders. This was not found for the two other inflammatory markers. The lifetime prevalence of male factor infertility and overall infertility were 10.2% and 17.9%, respectively. The findings suggest that male factor infertility might be associated with an increased level of interleukin-6.
- Subjects :
- Adult
Male
Infertility
medicine.medical_specialty
Denmark
Population
Disease
Systemic inflammation
Male infertility
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
030212 general & internal medicine
education
Infertility, Male
Inflammation
Gynecology
education.field_of_study
030219 obstetrics & reproductive medicine
biology
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
C-reactive protein
Confounding
Obstetrics and Gynecology
General Medicine
medicine.disease
C-Reactive Protein
Reproductive Medicine
biology.protein
Population study
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 17428149 and 14647273
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Human Fertility
- Accession number :
- edsair.doi.dedup.....96b432b243dcb82e729e778da4030723