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Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder: a CAN-BIND report
- Source :
- Neuropsychopharmacology
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Finding a clinically useful neuroimaging biomarker that can predict treatment response in patients with major depressive disorder (MDD) is challenging, in part because of poor reproducibility and generalizability of findings across studies. Previous work has suggested that posterior hippocampal volumes in depressed patients may be associated with antidepressant treatment outcomes. The primary purpose of this investigation was to examine further whether posterior hippocampal volumes predict remission following antidepressant treatment. Magnetic resonance imaging (MRI) scans from 196 patients with MDD and 110 healthy participants were obtained as part of the first study in the Canadian Biomarker Integration Network in Depression program (CAN-BIND 1) in which patients were treated for 16 weeks with open-label medication. Hippocampal volumes were measured using both a manual segmentation protocol and FreeSurfer 6.0. Baseline hippocampal tail (Ht) volumes were significantly smaller in patients with depression compared to healthy participants. Larger baseline Ht volumes were positively associated with remission status at weeks 8 and 16. Participants who achieved early sustained remission had significantly greater Ht volumes compared to those who did not achieve remission by week 16. Ht volume is a prognostic biomarker for antidepressant treatment outcomes in patients with MDD.
- Subjects :
- Adult
Male
Oncology
Canada
medicine.medical_specialty
Hippocampal formation
Hippocampus
Article
03 medical and health sciences
0302 clinical medicine
Neuroimaging
Predictive Value of Tests
Internal medicine
Humans
Medicine
Depression (differential diagnoses)
Pharmacology
Depressive Disorder, Major
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Antidepressive Agents
030227 psychiatry
Psychiatry and Mental health
Treatment Outcome
Predictive value of tests
Biomarker (medicine)
Antidepressant
Major depressive disorder
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1740634X and 0893133X
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....96bcef633af8c78b1cc7dfe199f1ffad