Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials

International audience; A simple and efficient way to synthesize peptidecontainingsilicone materials is described. Silicone oils containinga chosen ratio of bioactive peptide sequences wereprepared by acid-catalyzed copolymerization of dichlorodimethylsilane,hybrid dichloromethyl peptidosilane, and Si-(vinyl)- or SiH-functionalized monomers. Functionalized siliconeoils were first obtained and then, after hydrosilylationcross-linking, bioactive polydimethylsiloxane (PDMS)-basedmaterials were straightforwardly obtained. The introductionof an antibacterial peptide yielded PDMS materials showingactivity against Staphylococcus aureus. PDMS containing RGDligands showed improved cell-adhesion properties. This genericmethod was fully compatible with the stability of peptidesand thus opened the way to the synthesis of a widerange of biologically active silicones.