Reduced thiamine is a predictor for cognitive impairment of cerebral infarction

Objective Reduced thiamine (vitamin B1) had been reported to be associated with cognitive impairment caused by Alzheimer disease. Our study is to explore the association between thiamine and cognitive impairment after acute ischemic stroke. Materials and Methods One hundred and eighty two patients with acute cerebral infarction were recruited within the first 24 hr after admission. Thiamine and other vitamin Bs of peripheral blood samples were measured. Patients were divided into with poststroke cognitive impairment (PSCI) and non‐PSCI according to the score of MMSE and the degree of education. Results Reduced thiamine (
PSCI shows a high incidence on acute stage, and more than a half (54.4%) of patients suffered with PSCI. Reduced serum thiamine was associated with early cognitive impairment in patients with acute infarction after adjusting for potential confounding factors. Advanced age, lower education, diabetes mellitus, left hemisphere infarction, and higher NIHSS were also independent risk factors for PSCI.