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Changes in vaccination strategies contribute to the development of invasive pneumococcal disease in allogeneic hematopoietic stem cell transplantation recipients: a retrospective study for promoting vaccination
- Source :
- International Journal of Hematology. 114:263-270
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients are at high risk of developing invasive pneumococcal disease (IPD) with substantial morbidity and mortality. Pneumococcal polysaccharide vaccine (PPSV23) and pneumococcal conjugate vaccine (PCV13) are the primary prevention strategy. The difference between the Japanese and international guidelines is limited except when to start PCV13. However, Japanese data regarding the incidence of IPD after allo-HSCT that include vaccination status are limited. Therefore, we aimed to study the clinical characteristics of patients with IPD following allo-HSCT, focusing on unvaccinated patients. We retrospectively reviewed allo-HSCT recipients between April 2005 and December 2018 at Komagome Hospital. Among 1,091 recipients, 11 (1008/100,000 recipients) developed 13 episodes of IPD. The median period from the first allo-HSCT to the first IPD episode was 686 days (10-3040 days). Ten patients developed IPD before vaccination, and seven of these unvaccinated patients with late-onset IPD were ineligible for vaccination based on domestic guidelines. Although appropriate treatments resulted in a good short-term prognosis, most episodes of IPD developed in unvaccinated allo-HSCT recipients. Our data support the promotion of better adherence to the current guidelines and the importance of pneumococcal vaccination even years after allo-HSCT to protect against late-onset IPD.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
medicine.medical_treatment
Hematopoietic stem cell transplantation
medicine.disease_cause
Pneumococcal Infections
Pneumococcal conjugate vaccine
Pneumococcal Vaccines
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
Outcome Assessment, Health Care
Streptococcus pneumoniae
medicine
Humans
Transplantation, Homologous
Public Health Surveillance
Retrospective Studies
Hematology
business.industry
Incidence (epidemiology)
Vaccination
Hematopoietic Stem Cell Transplantation
Retrospective cohort study
Middle Aged
bacterial infections and mycoses
Pneumococcal polysaccharide vaccine
Transplant Recipients
surgical procedures, operative
030220 oncology & carcinogenesis
Female
Disease Susceptibility
business
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 18653774 and 09255710
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- International Journal of Hematology
- Accession number :
- edsair.doi.dedup.....96e8828a30bf8861898310e1f7988d82