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An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission
- Source :
- Cell Reports. 40:111385
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- The initial immune response to HIV determines transmission. However, due to technical limitations we still do not have a comparative map of early mucosal transmission events. By combining RNAscope, cyclic immunofluorescence, and image analysis tools, we quantify HIV transmission signatures in intact human colorectal explants within 2 h of topical exposure. We map HIV enrichment to mucosal dendritic cells (DCs) and submucosal macrophages, but not CD4
Details
- ISSN :
- 22111247
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Cell Reports
- Accession number :
- edsair.doi.dedup.....96ec6bce30be075eb9cc76cd90caad06