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Diagnostic value of alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index combined with γ-glutamyl transferase in differentiating ALD and NAFLD
- Source :
- The Korean Journal of Internal Medicine
- Publication Year :
- 2016
- Publisher :
- Korean Association of Internal Medicine, 2016.
-
Abstract
- Background/Aims: This study aimed to verify the reliability of the alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index (ANI) for distinguishing ALD in patients with hepatic steatosis from NAFLD, and to investigate whether ANI combined with γ-glutamyl transferase (GGT) would enhance the accuracy of diagnosis in China. Methods: A hundred thirty-nine cases of fatty liver disease (FLD) were divided into two groups of ALD and NAFLD. The ANI was calculated with an online calculator. All indicators and ANI values were analyzed using statistical methods. Results: ANI was significantly higher in patients with ALD than in those with NAFLD (7.11 ± 5.77 vs. –3.09 ± 3.89, p < 0.001). With a cut-off value of –0.22, the sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC) of diagnosed ALD cases was 87.1%, 92.5%, and 0.934 (95% confidence interval [CI], 0.879 to 0.969), respectively. The corresponding values for aspartate aminotransferase (AST)/alanine transaminase (ALT), mean corpuscular volume (MCV), and GGT were 75.29%, 72.94%, and 0.826 (95% CI, 0.752 to 0.885); 94.34%, 83.02%, and 0.814 (95% CI, 0.739 to 0.875) and 80.23%, 79.25%, and 0.815 (95% CI, 0.740 to 0.876), respectively. ANI AUROC was significantly higher than the AST/ALT, MCV, or GGT AUROCs (all p < 0.001), moreover, ANI showed better diagnostic performance. The combination of ANI and GGT showed a better AUROC than ANI alone (0.976 vs. 0.934, p = 0.016). The difference in AUROCs between AST/ALT, MCV, and GGT was not statistically significant (all p > 0.05). Conclusions: ANI can help distinguish ALD from NAFLD with high accuracy; when ANI was combined with GGT, its effectiveness improved further.
- Subjects :
- Male
Alcoholic liver disease
Biopsy
Diagnosis, differential
Severity of Illness Index
Gastroenterology
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
ALD/NAFLD index
Nonalcoholic fatty liver disease
Medicine
Prospective Studies
Gamma-glutamyltransferase
Ultrasonography
Observer Variation
medicine.diagnostic_test
biology
Middle Aged
Prognosis
γ glutamyl transferase
Area Under Curve
030220 oncology & carcinogenesis
Female
Original Article
030211 gastroenterology & hepatology
Adult
China
medicine.medical_specialty
digestive system
Decision Support Techniques
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Humans
In patient
Liver Diseases, Alcoholic
business.industry
Reproducibility of Results
nutritional and metabolic diseases
Clinical Enzyme Tests
medicine.disease
digestive system diseases
body regions
ROC Curve
biology.protein
Steatosis
Differential diagnosis
business
Biomarkers
Subjects
Details
- ISSN :
- 20056648 and 12263303
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- The Korean Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....971ab3b4ea3e6c835eba940d1c8788fb