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A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia
- Source :
- European respiratory journal, 49(2). European Respiratory Society, Paff, T, Daniels, J M A, Weersink, E J, Lutter, R, Noordegraaf, A V & Haarman, E G 2017, ' A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia ', European Respiratory Journal, vol. 49, no. 2, 1601770 . https://doi.org/10.1183/13993003.01770-2016, European Respiratory Journal, 49(2):1601770. European Respiratory Society
- Publication Year :
- 2017
- Publisher :
- European Respiratory Society (ERS), 2017.
-
Abstract
- Hypertonic saline inhalation lowers airway mucous viscosity. Increased cough transportability may improve quality of life (QoL) in primary ciliary dyskinesia (PCD).In this randomised controlled trial (RCT), PCD patients received twice-daily inhalations of hypertonic (7%) saline or isotonic (0.9%) saline for 12 weeks, with 4 weeks washout during crossover. Primary outcome was change in QoL measured by the St George's Respiratory Questionnaire (SGRQ) total score. Secondary outcomes were SGRQ subscores, Quality of Life Questionnaire-Bronchiectasis (QoL-B) scores, lower respiratory tract infection symptoms, exacerbations, spirometry, systemic and sputum inflammatory markers, adherence, and adverse events.There was no significant change in median (interquartile range) SGRQ total score between hypertonic saline (−2.6 (−9.0–1.5)) and isotonic saline (−0.3 (−8.1–6.1)) in 22 patients (age range 22–73 years) (p=0.38). QoL-B Health Perception scale improved with hypertonic saline (p=0.03). Adverse events occurred more frequently with hypertonic saline, but were mild.12 weeks of inhaled hypertonic saline did not improve SGRQ total score in adult PCD patients in this RCT, but the sample size was small. On the secondary and more disease-specific end-point of the QoL-B, a significant improvement was observed in the Health Perception scale. This study found little evidence to support the hypothesis that hypertonic saline improves QoL in PCD patients. We advise the use of disease-specific outcome measures in future trials.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_treatment
Severity of Illness Index
law.invention
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
Quality of life
law
Interquartile range
Surveys and Questionnaires
Administration, Inhalation
Humans
Medicine
030212 general & internal medicine
Adverse effect
Saline
Netherlands
Saline Solution, Hypertonic
Cross-Over Studies
medicine.diagnostic_test
Kartagener Syndrome
business.industry
Sputum
Middle Aged
Crossover study
humanities
Hypertonic saline
030228 respiratory system
Mucociliary Clearance
Anesthesia
Quality of Life
Female
business
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....971f2af215b4e8a449b4d0f109375b79