Back to Search
Start Over
Distinct expression and prognostic value of OTU domain-containing proteins in non-small-cell lung cancer
- Source :
- Oncology Letters
- Publication Year :
- 2018
-
Abstract
- The ubiquitin-proteasome pathway is an important protein degradation regulatory system in cells. This pathway is also a reversible process that is strictly regulated, and the regulation of deubiquitinating enzymes (DUBs) represents an important facet of the process. Ovarian tumor-associated proteases domain-containing proteins (OTUDs), as a subfamily within the DUB family, serve an important role in regulatory mechanisms of several biological processes, through the regulation of gene transcription, cell cycle, immune response, inflammation and tumor growth processes, and may be important in the diagnosis of various diseases and constitute novel drug targets. However, the role of OTUDs in non-small-cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the Oncomine database was used to examine gene expression in NSCLC, and the prognostic value of each gene was analyzed by Kaplan-Meier analysis. The results indicated that high mRNA expression levels of OTUD1, OTUD3, OTUD4 and putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 were associated with improved prognosis in all NSCLC and adenocarcinoma, but not in squamous cell carcinoma. By contrast, high expression levels of OTUD2 mRNA were associated with poorer overall survival in patients with NSCLC. These data suggested that these OTUD isozymes may be a potential drug target for NSCLC.
- Subjects :
- 0301 basic medicine
Cancer Research
expressed
Oncogene
Cancer
Articles
Biology
Cell cycle
Protein degradation
medicine.disease
Isozyme
ovarian tumor-associated proteases domain-containing protein
Deubiquitinating enzyme
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Oncology
non-small-cell lung cancer
030220 oncology & carcinogenesis
Gene expression
medicine
biology.protein
Cancer research
Adenocarcinoma
prognosis
Subjects
Details
- ISSN :
- 17921074
- Volume :
- 18
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Oncology letters
- Accession number :
- edsair.doi.dedup.....97221dba46bc95674b4d4839cc6f0a6f