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Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets
- Source :
- Exploration of Targeted Anti-tumor Therapy, Vol 2, Iss 3 (2021)
- Publication Year :
- 2021
-
Abstract
- Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transition, metabolic remodeling, cancer cell intercommunication and the tumor microenvironment including diverse stromal cells, are reported to affect the metastatic process of cancer cells. Calcium ions (Ca2+) are ubiquitous second messengers that manipulate cancer metastasis by affecting signaling pathways. Diverse transporter/pump/channel-mediated Ca2+ currents form Ca2+ oscillations that can be decoded by Ca2+-binding proteins, which are promising prognostic biomarkers and therapeutic targets of cancer metastasis. This paper presents a review of the advances in research on the mechanisms underlying cancer metastasis and the roles of Ca2+-related signals in these events.
- Subjects :
- 0301 basic medicine
business.industry
epithelial-mesenchymal transition
Cancer therapy
Tumor therapy
Cancer metastasis
immunosurveillance
RC31-1245
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
cancer metastasis
030220 oncology & carcinogenesis
Cancer research
tumor microenvironment
Medicine
calcium channel
business
Internal medicine
metastatic colonization
Calcium signaling
Subjects
Details
- ISSN :
- 26923114
- Volume :
- 2
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Exploration of targeted anti-tumor therapy
- Accession number :
- edsair.doi.dedup.....9726de94b65a0823687d3d589cbd417f