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Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets

Authors :
Jinghang Zhang
Gang Liu
Shuhong Zhang
Xianwei Wang
Chaochu Cui
Yongxi Zhang
Source :
Exploration of Targeted Anti-tumor Therapy, Vol 2, Iss 3 (2021)
Publication Year :
2021

Abstract

Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transition, metabolic remodeling, cancer cell intercommunication and the tumor microenvironment including diverse stromal cells, are reported to affect the metastatic process of cancer cells. Calcium ions (Ca2+) are ubiquitous second messengers that manipulate cancer metastasis by affecting signaling pathways. Diverse transporter/pump/channel-mediated Ca2+ currents form Ca2+ oscillations that can be decoded by Ca2+-binding proteins, which are promising prognostic biomarkers and therapeutic targets of cancer metastasis. This paper presents a review of the advances in research on the mechanisms underlying cancer metastasis and the roles of Ca2+-related signals in these events.

Details

ISSN :
26923114
Volume :
2
Issue :
3
Database :
OpenAIRE
Journal :
Exploration of targeted anti-tumor therapy
Accession number :
edsair.doi.dedup.....9726de94b65a0823687d3d589cbd417f