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New insights on the effects of spinosad on the development of Helicoverpa armigera
- Source :
- Ecotoxicology and Environmental Safety, Vol 221, Iss, Pp 112452-(2021)
- Publication Year :
- 2021
-
Abstract
- Helicoverpa armigera (cotton bollworm) is one of the most destructive pests worldwide. Due to resistance to Bacillus thuringiensis and conventional insecticides, an effective management strategy to control this pest is urgently needed. Spinosad, a natural pesticide, is considered an alternative; however, the mechanism underlying the developmental effects of sublethal spinosad exposure remains elusive. In this study, the mechanism was examined using an insect model of H. armigera. Results confirmed that exposure to sublethal spinosad led to reduced larval wet weight, delayed larval developmental period, caused difficulty in molting, and deformed pupae. Further investigation demonstrated that exposure to sublethal spinosad caused a significant decrease in 20E titer and increase in JH titer, thereby leading to the discordance between 20E and JH titers, and consequently alteration in the expression levels of HR3 and Kr-h1. These results suggested that sublethal spinosad caused hormonal disorders in larvae, which directly affect insect development. Our study serves as a reference and basis for the toxicity evaluation of spinosad on molting and pupation in insect metamorphosis, which may contribute to identifying targets for effective control of cotton bollworm.
- Subjects :
- Developmental effects
Insecticides
Health, Toxicology and Mutagenesis
media_common.quotation_subject
0211 other engineering and technologies
20-Hydroxyecdysone
Spinosad
02 engineering and technology
010501 environmental sciences
Helicoverpa armigera
Molting
Moths
01 natural sciences
Environmental pollution
Toxicology
chemistry.chemical_compound
Bacillus thuringiensis
medicine
Animals
GE1-350
Metamorphosis
0105 earth and related environmental sciences
media_common
021110 strategic, defence & security studies
Larva
biology
fungi
Public Health, Environmental and Occupational Health
Pupa
General Medicine
Pesticide
biology.organism_classification
Pollution
Environmental sciences
Drug Combinations
chemistry
TD172-193.5
Juvenile hormone
PEST analysis
Macrolides
20-hydroxyecdysone
medicine.drug
Subjects
Details
- ISSN :
- 10902414
- Volume :
- 221
- Database :
- OpenAIRE
- Journal :
- Ecotoxicology and environmental safety
- Accession number :
- edsair.doi.dedup.....97274b026eb6378a307f664451f042bf