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Bovine and murine tissue expression of insulin like growth factor-I
- Source :
- Gene. 535(2)
- Publication Year :
- 2013
-
Abstract
- The genomic architecture and expression of the Igf-1 gene are complex yielding multiple IGF-I transcript isoforms with putative functional contributions to growth and metabolism. Using RNA-seq on different tissues, physiological states, and species, the breadth of transcripts expressed was determined. Tissues from pre- and post-pubertal heifers and mature mice were collected and the transcript isoforms characterized. Three different IGF-I isoforms were detected in heifers with Class 1 transcripts most abundantly expressed. The pituitary reduced IGF-I expression post-pubertally whereas the uterus increased expression. Murine IGF-I transcript expression was more diverse utilizing multiple exons, start sites, and 3'UTRs. The RNA-seq methodology to characterize expression profiles permits assessment of the transcript isoforms yielding insight into functional roles of each transcript.
- Subjects :
- Gene isoform
medicine.medical_treatment
Alternative splicing
Uterus
RNA-Seq
General Medicine
Metabolism
Biology
Molecular biology
Insulin-like growth factor
Exon
Alternative Splicing
Mice
medicine.anatomical_structure
Organ Specificity
Gene Order
Genetics
medicine
Animals
Cattle
Female
RNA, Messenger
Sexual Maturation
Insulin-Like Growth Factor I
Gene
Subjects
Details
- ISSN :
- 18790038
- Volume :
- 535
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....9731819f93b373018ce70445798ccc30