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The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects
- Source :
- Frontiers in Physiology, Frontiers in Physiology, 2020, 11, ⟨10.3389/fphys.2020.591850⟩, Frontiers in Physiology, Frontiers, 2020, 11, ⟨10.3389/fphys.2020.591850⟩, Frontiers in Physiology, Frontiers, 2020, 11, pp.591850. ⟨10.3389/fphys.2020.591850⟩, Frontiers in Physiology, 2020, 11, pp.591850. ⟨10.3389/fphys.2020.591850⟩, Frontiers in Physiology, Vol 11 (2020)
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; Vasculogenesis and angiogenesis are key processes of placental development, which occur throughout pregnancy. Placental vasculogenesis occurs during the first trimester of pregnancy culminating in the formation of hemangioblasts from intra-villous stem cells. Placental angiogenesis occurs subsequently, forming new blood vessels from existing ones. Angiogenesis also takes place at the fetomaternal interface, allowing essential spiral arteriole remodeling to establish the fetomaternal circulation. Vasculogenesis and angiogenesis in animal models and in humans have been studied in a wide variety of in vitro, physiological and pathological conditions, with a focus on the pro- and anti-angiogenic factors that control these processes. Recent studies revealed roles for new families of proteins, including direct participants such as the prokineticin family, and regulators of these processes such as the homeobox genes. This review summarizes recent advances in understanding the molecular mechanisms of actions of these families of proteins. Over the past decade, evidence suggests increased production of placental anti-angiogenic factors, as well as angiogenic factors are associated with fetal growth restriction (FGR) and preeclampsia (PE): the most threatening pathologies of human pregnancy with systemic vascular dysfunction. This review also reports novel clinical strategies targeting members of these family of proteins to treat PE and its consequent effects on the maternal vascular system.
- Subjects :
- 0301 basic medicine
Physiology
Angiogenesis
Mini Review
[SDV]Life Sciences [q-bio]
030209 endocrinology & metabolism
Biology
Bioinformatics
lcsh:Physiology
Preeclampsia
angiogenesis
03 medical and health sciences
0302 clinical medicine
Vasculogenesis
vascularization
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Physiology (medical)
Placenta
medicine
EG-VEGF
ComputingMilieux_MISCELLANEOUS
prokineticins
lcsh:QP1-981
[SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
homeobox genes
medicine.disease
Prokineticin
endothelial cells
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
3. Good health
vessel development
[SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
030104 developmental biology
medicine.anatomical_structure
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Hemangioblast
Homeobox
pregnancy
Stem cell
Subjects
Details
- Language :
- English
- ISSN :
- 1664042X
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physiology, Frontiers in Physiology, 2020, 11, ⟨10.3389/fphys.2020.591850⟩, Frontiers in Physiology, Frontiers, 2020, 11, ⟨10.3389/fphys.2020.591850⟩, Frontiers in Physiology, Frontiers, 2020, 11, pp.591850. ⟨10.3389/fphys.2020.591850⟩, Frontiers in Physiology, 2020, 11, pp.591850. ⟨10.3389/fphys.2020.591850⟩, Frontiers in Physiology, Vol 11 (2020)
- Accession number :
- edsair.doi.dedup.....97470872eb0038a43b83977791e2012c