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Tolerability of buprenorphine transdermal system in nursing home patients with advanced dementia: a randomized, placebo-controlled trial (DEP.PAIN.DEM)
- Source :
- Clinical Interventions in Aging
- Publication Year :
- 2018
- Publisher :
- Dove Press, 2018.
-
Abstract
- Ane Erdal,1 Elisabeth Flo,2 Dag Aarsland,3,4 Geir Selbaek,5–7 Clive Ballard,8 Dagrun D Slettebo,1 Bettina S Husebo1,9 1Department of Global Public Health and Primary Care, Centre for Elderly and Nursing Home Medicine, University of Bergen, Bergen, Norway; 2Department of Clinical Psychology, University of Bergen, Bergen, Norway; 3Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; 4Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; 5Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway; 6National Advisory Unit on Aging and Health, Tønsberg, Norway; 7Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway; 8Exeter Medical School, University of Exeter, Exeter, UK; 9Municipality of Bergen, Bergen, Norway Purpose: Buprenorphine transdermal system is increasingly prescribed in people with advanced dementia, but no clinical trial has investigated the safety and factors associated with discontinuation due to adverse events in this population. Patients and methods: One hundred sixty-two people with advanced dementia and significant depression from 47 nursing homes were included and randomized to active analgesic treatment (acetaminophen/buprenorphine) or identical placebo for 13 weeks. In this secondary analysis, the main outcomes were time to and reasons for discontinuation of buprenorphine due to adverse events. Change in daytime activity as measured by actigraphy was a secondary outcome. Results: Of the 44 patients who received active buprenorphine 5 μg/hour, 52.3% (n=23) discontinued treatment due to adverse events compared to 13.3% (6 of 45) in the placebo group (p
- Subjects :
- Male
medicine.medical_specialty
drug safety
Analgesic
Population
Placebo-controlled study
Pain
Placebo
Administration, Cutaneous
03 medical and health sciences
0302 clinical medicine
Drug Delivery Systems
Internal medicine
medicine
Humans
030212 general & internal medicine
Adverse effect
education
Original Research
Aged
Pain Measurement
education.field_of_study
adverse drug reactions
business.industry
opioids
General Medicine
Discontinuation
Buprenorphine
Nursing Homes
Analgesics, Opioid
Tolerability
Clinical Interventions in Aging
analgesics
Female
Dementia
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 11781998
- Database :
- OpenAIRE
- Journal :
- Clinical Interventions in Aging
- Accession number :
- edsair.doi.dedup.....97592625b46d1620def7018e6be8c5a4