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Two new clerodane-type diterpenoids from Bornean liverwort Gottschelia schizopleura and their cytotoxic activity
- Source :
- Natural product research. 32(15)
- Publication Year :
- 2017
-
Abstract
- The Bornean liverwort Gottschelia schizopleura was investigated phytochemically for the first time. Two new and four previously known clerodane-type diterpenoids were isolated from the MeOH extract of G. schizopleura through a series of chromatographic techniques. The structures of the new metabolites were established by analyses of their spectroscopic data (1D NMR, 2D NMR, HRESIMS and IR). All the isolated compounds 1–6 were tested against human promyelocytic leukaemia (HL-60), human colon adenocarcinoma (HT-29) and Mus musculus skin melanoma (B16-F10). Compound 1 and 2 showed active inhibition against HL-60 and B16-F10 cells.
- Subjects :
- 0106 biological sciences
Hepatophyta
Spectrometry, Mass, Electrospray Ionization
Magnetic Resonance Spectroscopy
Stereochemistry
Antineoplastic Agents
HL-60 Cells
Plant Science
01 natural sciences
Biochemistry
Analytical Chemistry
Diterpenes, Clerodane
Mice
MUS MUSCULUS SKIN
Cell Line, Tumor
Cytotoxic T cell
Animals
Humans
biology
Molecular Structure
010405 organic chemistry
Chemistry
Organic Chemistry
Jungermanniaceae
Nuclear magnetic resonance spectroscopy
biology.organism_classification
Gottschelia schizopleura
0104 chemical sciences
Drug Screening Assays, Antitumor
Two-dimensional nuclear magnetic resonance spectroscopy
Human colon
010606 plant biology & botany
Subjects
Details
- ISSN :
- 14786427
- Volume :
- 32
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Natural product research
- Accession number :
- edsair.doi.dedup.....9785088e75f0e1087ab09ce5c01d4c11