Thiocamptothecin

Authors :: Cristian Samorì
Andrea Guerrini
Greta Varchi
Franco Zunino
Giovanni Luca Beretta
Cristina Femoni
Ezio Bombardelli
Gabriele Fontana
Arturo Battaglia
C. Samorì
A. Guerrini
G. Varchi
F. Zunino
G. L. Beretta
C. Femoni
E. Bombardelli
G. Fontana
A. Battaglia
Source :: Journal of medicinal chemistry 51 (2008): 3040–3044. doi:10.1021/jm8001982, info:cnr-pdr/source/autori:Cristian Samorì (1); Andrea Guerrini (1); Greta Varchi (1); Franco Zunino (2); Giovanni Luca Beretta (2); Cristina Femoni (3); Ezio Bombardelli (4); Gabriele Fontana (4); Arturo Battaglia (1)/titolo:Thiocamptothecin/doi:10.1021%2Fjm8001982/rivista:Journal of medicinal chemistry/anno:2008/pagina_da:3040/pagina_a:3044/intervallo_pagine:3040–3044/volume:51
Publication Year :: 2008
Publisher :: American Chemical Society (ACS), 2008.
Abstract: The synthesis and the X-ray structure of 16a-thiocamptothecin (TCPT), the thiopyridone analog of camptothecin (CPT), are accomplished. The crystal contains two structurally identical, yet independent molecules. Both of them are connected to other molecules via two intermolecular hydrogen bonds. S-methylation of TCPT leads to the cleavage of the C-ring. The cytotoxic activity of TCPT was evaluated against different human tumor cell lines using CPT as reference compound.