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Micronutrient–gene interactions related to inflammatory/immune response and antioxidant activity in ageing and inflammation. A systematic review
- Source :
- Mechanisms of Ageing and Development. :29-49
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Recent longitudinal studies in dietary daily intake in human centenarians have shown that a satisfactory content of some micronutrients within the cells maintain several immune functions, a low grade of inflammation and preserve antioxidant activity. Micronutrients (zinc, copper, selenium) play a pivotal role in maintaining and reinforcing the performances of the immune and antioxidant systems as well as in affecting the complex network of the genes (nutrigenomic) with anti- and pro-inflammatory tasks. Genes of pro- and anti-inflammatory cytokines and some key regulators of trace elements homeostasis, such as Metallothioneins (MT), are involved in the susceptibility to major geriatric disease/disorders. Moreover, the genetic inter-individual variability may affect the nutrients’ absorption (nutrigenetic) with altered effects on inflammatory/immune response and antioxidant activity. The interaction between genetic factors and micronutrients (nutrigenomic and nutrigenetic approaches) may influence ageing and longevity because the micronutrients may become also toxic. This review reports the micronutrient–gene interactions in ageing and their impact on the healthy state with a focus on the method of protein–metal speciation analysis. The association between micronutrient–gene interactions and the protein–metal speciation analysis can give a complete picture for a personalized nutrient supplementation or chelation in order to reach healthy ageing and longevity.
- Subjects :
- Aging
Antioxidant
medicine.medical_treatment
media_common.quotation_subject
Longevity
Inflammation
Disease
Biology
Antioxidants
Selenium
Nutrigenomics
Nutrient
Immune system
medicine
Humans
Micronutrients
Aged
Chelating Agents
media_common
Aged, 80 and over
Micronutrient
Zinc
Ageing
Immune System
Dietary Supplements
Immunology
medicine.symptom
Copper
Developmental Biology
Subjects
Details
- ISSN :
- 00476374
- Database :
- OpenAIRE
- Journal :
- Mechanisms of Ageing and Development
- Accession number :
- edsair.doi.dedup.....97c715792c93d39b1ab20d1204231aa8