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High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22
- Source :
- PLoS ONE, Vol 6, Iss 8, p e23737 (2011), PLoS ONE
- Publication Year :
- 2011
- Publisher :
- Public Library of Science (PLoS), 2011.
-
Abstract
- Interleukin 22 (IL-22) is a T-cell secreted cytokine that modulates inflammatory response in nonhematopoietic tissues such as epithelium and liver. The function of IL-22 in adipose tissue is currently unknown. We generated a transgenic mouse model with overexpression of IL-22 specifically in adipose tissue. The IL-22 transgenic mice had no apparent changes in obesity and insulin resistance after feeding with high fat diet (HFD). Unexpectedly, all the IL-22 transgenic mice fed with HFD for four months developed spontaneous tumors in epididymal adipose tissue. Histological analysis indicated that the tumors were well-differentiated liposarcomas with infiltration of inflammatory cells. IL-22 overexpression promotes production of inflammatory cytokines such as IL-1β and IL-10 and stimulates ERK phosphorylation in adipose tissue. Furthermore, IL-22 treatment in differentiated 3T3-L1 adipocytes could induce IL-1β and IL-10 expression, together with stimulation of ERK phosphorylation. Taken together, our study not only established a novel mouse model with spontaneous liposarcoma, but also revealed that IL-22 overexpression may collaborate with diet-induced obesity to impact on tumor development in mouse.
- Subjects :
- Genetically modified mouse
Lifestyle Causes of Cancer
Male
medicine.medical_specialty
Mouse
Adipose tissue macrophages
Immunology
Adipose tissue
Gene Expression
lcsh:Medicine
Inflammation
Mice, Transgenic
Biology
Diet, High-Fat
Proinflammatory cytokine
Mice
Model Organisms
Internal medicine
Bone and Soft Tissue Sarcomas
Basic Cancer Research
medicine
Adipocytes
Animals
Phosphorylation
Extracellular Signal-Regulated MAP Kinases
lcsh:Science
Nutrition
Multidisciplinary
Cancer Risk Factors
Interleukins
lcsh:R
Interleukin
Cancers and Neoplasms
Animal Models
Liposarcoma
Epithelium
Interleukin 10
Endocrinology
medicine.anatomical_structure
Oncology
Adipose Tissue
Immune System
Cytokines
Medicine
lcsh:Q
medicine.symptom
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....97ca189f5b0a9ee8f7376827fc4c1515