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Identification of Potential Helicoverpa armigera (Lepidoptera: Noctuidae) Sterol Carrier Protein-2 Inhibitors Through High-Throughput Virtual Screening

Authors :
Jun Cai
Du Xin
Lin Jianguo
Du Xinkai
Wang Changgao
Source :
Journal of Economic Entomology. 110:1779-1784
Publication Year :
2017
Publisher :
Oxford University Press (OUP), 2017.

Abstract

Helicoverpa armigera sterol carrier protein-2 (HaSCP-2) is a validated target for development of novel insecticides due to its divergent protein structure and function from the vertebrate SCP-2. HaSCP-2 is important for normal development and fertility in Helicoverpa armigera (Hübner). The discovery of chemical inhibitors of HaSCP-2 through a structure-based virtual screening is reported here. Bioassay indicated that H1 and H14 had inhibitory effect on the growth of H. armigera larvae. The results suggest that H1 and H14 are promising as useful lead compounds for further optimization and development of novel SCP-2-specific pesticides.

Details

ISSN :
1938291X and 00220493
Volume :
110
Database :
OpenAIRE
Journal :
Journal of Economic Entomology
Accession number :
edsair.doi.dedup.....97d0dcee757c240996c5cfaf5aa964f9
Full Text :
https://doi.org/10.1093/jee/tox157