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Defining specificity of transcription factor regulatory activities
- Source :
- Journal of Cell Science, Journal of Cell Science, Company of Biologists, 2009, 122 (Pt 22), pp.4027-34. ⟨10.1242/jcs.054916⟩, Journal of Cell Science, 2009, 122 (Pt 22), pp.4027-34. ⟨10.1242/jcs.054916⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; Mammalian transcription factors (TFs) are often involved in differential cell-type- and context-specific transcriptional responses. Recent large-scale comparative studies of TF recruitment to the genome, and of chromatin structure and gene expression, have allowed a better understanding of the general rules that underlie the differential activities of a given TF. It has emerged that chromatin structure dictates the differential binding of a given TF to cell-type-specific cis-regulatory elements. The subsequent regulation of TF activity then ensures the functional activation of only the precise subset of all regulatory sites bound by the TF that are required to mediate appropriate gene expression. Ultimately, the organization of the genome within the nucleus, and crosstalk between different cis-regulatory regions involved in gene regulation, also participate in establishing a specific transcriptional program. In this Commentary, we discuss how the integration of these different and probably intimately linked regulatory mechanisms allow for TF cell-type- and context-specific modulation of gene expression.
- Subjects :
- Transcription, Genetic
Computational biology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Genome
03 medical and health sciences
0302 clinical medicine
Transcription (biology)
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Gene expression
Transcription factors
Animals
Humans
Transcription factor
ChIA-PET
030304 developmental biology
Genetics
Regulation of gene expression
0303 health sciences
Molecular Structure
Functional genomics
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
Cell Biology
Chromatin
Enhancer Elements, Genetic
Cell-type-specific transcription
Gene Expression Regulation
Organ Specificity
Coactivators
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 00219533 and 14779137
- Database :
- OpenAIRE
- Journal :
- Journal of Cell Science, Journal of Cell Science, Company of Biologists, 2009, 122 (Pt 22), pp.4027-34. ⟨10.1242/jcs.054916⟩, Journal of Cell Science, 2009, 122 (Pt 22), pp.4027-34. ⟨10.1242/jcs.054916⟩
- Accession number :
- edsair.doi.dedup.....97dc309f2bd590d0ee59591f059847c9