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Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community
- Source :
- European Journal of Cardiovascular Prevention & Rehabilitation. 18:664-673
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- Salt sensitivity, a trait characterized by a pressor blood pressure response to increased dietary salt intake, has been associated with higher rates of cardiovascular target organ damage and cardiovascular disease events. Recent experimental studies have highlighted the potential role of the natriuretic peptides and aldosterone in mediating salt sensitivity.Prospective cohort study.We evaluated 1575 non-hypertensive Framingham Offspring cohort participants (mean age 55 ± 9 years, 58% women) who underwent routine measurements of circulating aldosterone and N-terminal proatrial natriuretic peptide (NT-ANP) and assessment of dietary sodium intake. Participants were categorized as potentially 'salt sensitive' if their serum aldosterone wassex-specific median but plasma NT-ANP was ≤sex-specific median value. Dietary sodium intake was categorized as lower versus higher (dichotomized at the sex-specific median). We used multivariable linear regression to relate presence of salt sensitivity (as defined above) to longitudinal changes (Δ) in systolic and diastolic blood pressure on follow-up (median four years).Participants who were 'salt sensitive' (N = 437) experienced significantly greater increases in blood pressure (Δ systolic, +4.4 and +2.3 mmHg; Δ diastolic, +1.9 and -0.3 mmHg; on a higher versus lower sodium diet, respectively) as compared to the other participants (Δ systolic, +2.8 and +1.0 mmHg; Δ diastolic, +0.5 and -0.2 mmHg; on higher versus lower sodium diet, respectively; P = 0.033 and P = 0.0127 for differences between groups in Δ systolic and Δ diastolic blood pressure, respectively).Our observational data suggest that higher circulating aldosterone and lower NT-ANP concentrations may be markers of salt sensitivity in the community. Additional studies are warranted to confirm these observations.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Epidemiology
medicine.drug_class
Offspring
Down-Regulation
Blood Pressure
Risk Assessment
Article
chemistry.chemical_compound
Sex Factors
Risk Factors
Internal medicine
Natriuretic peptide
medicine
Humans
Prospective Studies
Protein Precursors
Sodium Chloride, Dietary
Prospective cohort study
Aldosterone
Aged
Framingham Risk Score
business.industry
Middle Aged
Prognosis
Up-Regulation
Endocrinology
Blood pressure
Massachusetts
chemistry
Salt sensitivity
Hypertension
Cohort
Linear Models
Female
Cardiology and Cardiovascular Medicine
business
Atrial Natriuretic Factor
Biomarkers
Subjects
Details
- ISSN :
- 17418267
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- European Journal of Cardiovascular Prevention & Rehabilitation
- Accession number :
- edsair.doi.dedup.....97df79d4fc36a49ac9393ac12e551e97