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Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein
- Source :
- Journal of Neuroimmunology. 235:33-39
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Thymic B cells represent a numerically minor cell population located primarily at the cortico-medullary junction. Their biological role is unclear. B cell-deficient μMT mice exhibited reduced medullary thymic epithelial cell (mTEC) numbers and reduced MOG and insulin mRNA expression. Lymphotoxin produced by B cells was critical for normal tissue restricted antigen (TRA) expression, suggesting that B cells regulate self-antigens through their production of LT. These results reveal an unexpected role of B cells in mTEC maintenance and expression of TRAs through their production of LT.
- Subjects :
- medicine.medical_specialty
Immunology
Cell
Population
Naive B cell
B-Lymphocyte Subsets
Mice, Nude
Thymus Gland
Biology
Article
Myelin oligodendrocyte glycoprotein
Mice
Antigen
Internal medicine
medicine
Animals
Immunology and Allergy
Lymphocyte Count
RNA, Messenger
education
Mice, Knockout
Transplantation Chimera
education.field_of_study
Myelin-associated glycoprotein
Autoimmune regulator
Cell biology
Mice, Inbred C57BL
Myelin-Associated Glycoprotein
medicine.anatomical_structure
Endocrinology
Lymphotoxin
Neurology
biology.protein
Female
Myelin-Oligodendrocyte Glycoprotein
Neurology (clinical)
Myelin Proteins
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 235
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....97e42de25f83d0d3beb1cf2569590f18