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Elevated serum level of growth arrest-specific protein 6 (Gas6) in systemic lupus erythematosus patients is associated with nephritis and cutaneous vasculitis
- Source :
- Rheumatology international. 34(5)
- Publication Year :
- 2013
-
Abstract
- Growth arrest-specific protein 6 (Gas6) is a serum protein involved in granulocyte, platelet and endothelium interaction, and is implicated in both anti-inflammatory response as well as platelet/leukocytes activation. We investigated serum Gas6 level in different clinical manifestations of systemic lupus erythematosus (SLE). Data were collected in 83 patients with SLE and 40 non-lupus controls. The Gas6 levels were detected by enzyme-linked immunosorbent assay. Our results demonstrated that the Gas6 level was higher in SLE patients as compared to the non-lupus control subjects (SLE vs. non-lupus control, median [inter-quartile range (IQR)] 22.67 [19.40–28.60] vs. 18.97 [16.05–20.62] ng/mL, p
- Subjects :
- Adult
Male
Vasculitis
medicine.medical_specialty
Immunology
Lupus nephritis
Granulocyte
Rheumatology
immune system diseases
Internal medicine
medicine
Immunology and Allergy
Humans
Lupus Erythematosus, Systemic
Platelet
skin and connective tissue diseases
Lupus erythematosus
business.industry
Case-control study
Middle Aged
medicine.disease
Prognosis
Lupus Nephritis
Up-Regulation
medicine.anatomical_structure
Case-Control Studies
Disease Progression
Intercellular Signaling Peptides and Proteins
Female
business
Nephritis
Biomarkers
Subjects
Details
- ISSN :
- 1437160X
- Volume :
- 34
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Rheumatology international
- Accession number :
- edsair.doi.dedup.....97eacc3da0d325f1cd2cf67259a9b47b