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Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature

Authors :
Leonardo Resta
Giuseppe Ingravallo
Senia Trabucco
Anna Colagrande
Gerardo Cazzato
Debora Brascia
Giuseppe Marulli
Giulia De Iaco
Francesca Signore
Source :
Medicina, Vol 57, Iss 524, p 524 (2021), Medicina
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Pulmonary sclerosing pneumocytoma is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and its histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging. We report our experience of two cases of sclerosing pneumocytoma, as well as a review of the literature. Immunohistochemical findings showed intense staining of the cuboidal epithelial cells for cytokeratin-pool and TTF-1, with focal positivity for progesterone receptors. Round and spindle cells expressed positivity for vimentin, TTF-1 and focally for the progesterone receptor. Cytologic diagnosis of pulmonary pneumocytoma requires the identification of its dual cell population, made up of abundant stromal cells and fewer surface cells. Since the pre- and intraoperative diagnosis should guide surgical decision making, obtaining a sufficient specimen size to find representative material in the cell block is of paramount importance.

Details

Language :
English
ISSN :
16489144
Volume :
57
Issue :
524
Database :
OpenAIRE
Journal :
Medicina
Accession number :
edsair.doi.dedup.....97fd066830ba568b93c50b187fdb8938