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Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature
- Source :
- Medicina, Vol 57, Iss 524, p 524 (2021), Medicina
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Pulmonary sclerosing pneumocytoma is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and its histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging. We report our experience of two cases of sclerosing pneumocytoma, as well as a review of the literature. Immunohistochemical findings showed intense staining of the cuboidal epithelial cells for cytokeratin-pool and TTF-1, with focal positivity for progesterone receptors. Round and spindle cells expressed positivity for vimentin, TTF-1 and focally for the progesterone receptor. Cytologic diagnosis of pulmonary pneumocytoma requires the identification of its dual cell population, made up of abundant stromal cells and fewer surface cells. Since the pre- and intraoperative diagnosis should guide surgical decision making, obtaining a sufficient specimen size to find representative material in the cell block is of paramount importance.
- Subjects :
- Pathology
medicine.medical_specialty
Medicine (General)
Stromal cell
Lung Neoplasms
Carcinoid tumors
Population
Review
Adenocarcinoma
pulmonary sclerosing pneumocytoma
lung tumor
Diagnosis, Differential
R5-920
Pulmonary Sclerosing Hemangioma
Progesterone receptor
medicine
Humans
fine-needle aspiration
education
Lung
education.field_of_study
medicine.diagnostic_test
business.industry
General Medicine
aspiration cytology
medicine.disease
Fine-needle aspiration
Immunohistochemistry
Differential diagnosis
business
Subjects
Details
- Language :
- English
- ISSN :
- 16489144
- Volume :
- 57
- Issue :
- 524
- Database :
- OpenAIRE
- Journal :
- Medicina
- Accession number :
- edsair.doi.dedup.....97fd066830ba568b93c50b187fdb8938