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Effect of an aqueous extract of Chrysobalanus icaco on the adiposity of Wistar rats fed a high-fat diet
- Source :
- Nutrición Hospitalaria v.37 n.4 2020, SciELO España. Revistas Científicas Españolas de Ciencias de la Salud, instname, SciELO España: Revistas Científicas Españolas de Ciencias de la Salud, Instituto de Salud Carlos III (ISCIII)
- Publication Year :
- 2020
-
Abstract
- espanolObjetivo: el objetivo de este estudio fue investigar los efectos del extracto acuoso de Chrysobalanus icaco (AECI) en la adiposidad y su mecanismo de accion en la expresion genica y proteica de la acetil-CoA-carboxilasa (ACC), una enzima clave para la lipogenesis. Metodos: se usaron ratones macho Wistar que se asignaron a una dieta estandar de control (CG) o a una rica en grasa (HFD). La HFD se trato con solucion salina o con extracto acuoso de Chrysobalanus icaco (AECI) durante cuatro semanas. Se evaluaron el peso corporal y el consumo alimentario. Se aislaron y analizaron muestras de tejido adiposo subcutaneo, retroperitoneal y periepididimico. Se determino la expresion genica y proteica de ACC en el tejido subcutaneo. Resultados: el AECI no mostro ningun efecto sobre la ingesta de alimento y tampoco sobre el peso corporal. Sin embargo, el tratamiento con AECI redujo el peso de los tejidos adiposos y la expresion genica y proteica de ACC, y mejoro tambien la tolerancia a la glucosa. Conclusion: Chrysobalanus icaco (AECI) resulto ser beneficioso para el tratamiento de la obesidad, previniendo el almacenamiento de grasa y mejorando la homeostasis glucemica. EnglishObjective: the purpose of this study was to investigate the effects of Chrysobalanus icaco on adiposity and its mechanism of action in the gene and protein expression of acetyl-CoA carboxylase (ACC), a key enzyme in lipogenesis. Method: Wistar rats were divided into a regular or control group (CG) and a high-fat diet (HFD) group. HFD was treated with saline or aqueous extract of Chrysobalanus icaco (AECI) for four weeks. Body weight and food intake were assessed. Subcutaneous, retroperitoneal and periepididymal adipose tissue samples were collected and weighed. Adipocytes from periepididymal tissue were isolated and analyzed. The gene and protein expression of ACC in subcutaneous tissue was determined. Results: AECI showed no effect on intake or body weight. However, the weight of the fat pads and the gene and protein expression of ACC were lower, and glucose tolerance was improved. Conclusion: the aqueous extract of Chrysobalanus icaco proved beneficial for the treatment of obesity, preventing fat storage and improving glycemic homeostasis.
- Subjects :
- 0301 basic medicine
Food intake
medicine.medical_specialty
Chrysobalanus icaco
Medicine (miscellaneous)
Adipose tissue
Gene Expression
030209 endocrinology & metabolism
Body weight
Diet, High-Fat
Chrysobalanaceae
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Gene and protein expression
Animals
Obesity
Rats, Wistar
Adiposity
Aqueous extract
030109 nutrition & dietetics
Nutrition and Dietetics
biology
Chemistry
Plant Extracts
Body Weight
biology.organism_classification
Rats
Endocrinology
Fat diet
Lipogenesis
Acetyl-CoA Carboxylase
Subjects
Details
- ISSN :
- 16995198
- Volume :
- 37
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Nutricion hospitalaria
- Accession number :
- edsair.doi.dedup.....9831584a9d80624a739be75f9f5464e7