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A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes
- Source :
- Organicbiomolecular chemistry. 5(1)
- Publication Year :
- 2006
-
Abstract
- A highly effective one-pot Friedlander quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66–100%).
Details
- ISSN :
- 14770520
- Volume :
- 5
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Organicbiomolecular chemistry
- Accession number :
- edsair.doi.dedup.....9847573610e389b608711996001fc0ae