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Anatomic Correlation of the Mini-Mental State Examination: A Voxel-Based Morphometric Study in Older Adults
- Source :
- PLoS ONE, PLoS ONE, Public Library of Science, 2016, 11 (10), pp.e0162889. ⟨10.1371/journal.pone.0162889⟩, PLoS ONE, Vol 11, Iss 10, p e0162889 (2016), Medical Biophysics Publications
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- The clinical utility of the Mini-Mental State Examination (MMSE) and its shorter version (SMMSE) is still debated. There is a need to better understand the neuroanatomical correlates of these cognitive tests. The objective of this cross-sectional study was to determine whether lower MMSE and SMMSE scores correlated with focal brain volume reduction in older adults. Participants from the GAIT study (n = 207; mean, 70.9±5.9 years; 57% female; mean MMSE 26.2±3.9; mean SMMSE 5.1±1.1) were evaluated using the MMSE and SMMSE and received a 1.5-Tesla MRI scan of the brain. Cortical gray and white matter subvolumes were automatically segmented using Statistical Parametric Mapping. Age, gender, education level, and total intracranial volume were included as potential confounders. We found correlations between the MMSE score and specific cortical regions of the limbic system including the hippocampus, amygdala, cingulate gyrus, and parahippocampal gyrus, independently of the diagnostic category (i.e., mild cognitive impairment or Alzheimer disease or controls). Regarding correlations with the SMMSE score, only one cluster in the left hippocampus was identified, which overlapped with the cluster that was positively correlated with the MMSE score. There were no correlations with the volume of white matter. In conclusion, worse MMSE and SMMSE scores were associated with gray matter atrophy mainly in the limbic system. This finding highlights that atrophy of specific brain regions are related to performance on the MMSE and the SMMSE tests, and provides new insights into the cognitive function probed by these tests.
- Subjects :
- 0301 basic medicine
Male
Central Nervous System
Pathology
[SDV]Life Sciences [q-bio]
lcsh:Medicine
Audiology
Hippocampus
Nervous System
Diagnostic Radiology
0302 clinical medicine
Limbic system
Cognition
Learning and Memory
Medicine and Health Sciences
Gray Matter
10. No inequality
lcsh:Science
ComputingMilieux_MISCELLANEOUS
Cognitive Impairment
Brain Mapping
Multidisciplinary
medicine.diagnostic_test
Cognitive Neurology
Radiology and Imaging
Brain
Neurodegenerative Diseases
Middle Aged
Amygdala
Magnetic Resonance Imaging
White Matter
Cognitive test
medicine.anatomical_structure
Neurology
Brain size
Female
Anatomy
Parahippocampal gyrus
Research Article
medicine.medical_specialty
Imaging Techniques
Cognitive Neuroscience
Brain Morphometry
Neuroimaging
Statistical parametric mapping
Research and Analysis Methods
White matter
03 medical and health sciences
Alzheimer Disease
Memory
Diagnostic Medicine
Mental Health and Psychiatry
mental disorders
medicine
Humans
Cognitive Dysfunction
Aged
Mini–Mental State Examination
business.industry
Morphometry
lcsh:R
Biology and Life Sciences
Voxel-based morphometry
030104 developmental biology
Cross-Sectional Studies
Cognitive Science
Dementia
lcsh:Q
business
Mental Status Schedule
Voxel-Based Morphometry
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, Public Library of Science, 2016, 11 (10), pp.e0162889. ⟨10.1371/journal.pone.0162889⟩, PLoS ONE, Vol 11, Iss 10, p e0162889 (2016), Medical Biophysics Publications
- Accession number :
- edsair.doi.dedup.....9849e18fb26cf96596530c549aa74f1f