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Advances in understanding and reducing the burden of severe asthma in children
- Source :
- The Lancet Respiratory Medicine, 8(10), 1032-1044. Elsevier Ltd.
- Publication Year :
- 2020
- Publisher :
- Elsevier Ltd., 2020.
-
Abstract
- Severe asthma in children is rare, accounting for only a small proportion of childhood asthma. After addressing modifiable factors such as adherence to treatment, comorbidities, and adverse exposures, children whose disease is not well controlled on high doses of medication form a heterogeneous group of severe asthma phenotypes. Over the past decade, considerable advances have been made in understanding the pathophysiology of severe therapy-resistant asthma in children. However, asthma attacks and hospital admissions are frequent and mortality is still unacceptably high. Strategies to modify the natural history of asthma, prevent severe exacerbations, and prevent lung function decline are needed. Mechanistic studies have led to the development of several biologics targeting type 2 inflammation. This growing pipeline has the potential to reduce the burden of severe asthma; however, detailed assessment and characterisation of each child with seemingly severe asthma is necessary so that the most effective and appropriate management strategy can be implemented. Risk stratification, remote monitoring, and the integration of multiple data sources could help to tailor management for the individual child with severe asthma.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
Severe asthma
macromolecular substances
Disease
03 medical and health sciences
0302 clinical medicine
immune system diseases
medicine
High doses
Humans
030212 general & internal medicine
Anti-Asthmatic Agents
Intensive care medicine
Child
Lung function
Asthma
Childhood asthma
business.industry
medicine.disease
respiratory tract diseases
Natural history
Hospitalization
Multiple data
030228 respiratory system
Child, Preschool
Disease Progression
business
Subjects
Details
- Language :
- English
- ISSN :
- 22132619 and 22132600
- Volume :
- 8
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The Lancet Respiratory Medicine
- Accession number :
- edsair.doi.dedup.....986b2b732a81e37ea3d76bc51df8186c