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Treatment of Recurrent Adenocarcinoma of the Endometrium with Pelvic Exenteration
- Source :
- Gynecologic Oncology. 60:288-291
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Women with recurrent endometrial carcinoma are usually not considered candidates for pelvic exenteration. To assess the efficacy of this procedure, the records of all patients undergoing pelvic exenteration for adenocarcinoma of the endometrium at four institutions from 1955 through 1988 were reviewed. Of the 31 procedures performed, 7 were for primary therapy and 4 were judged to be palliative in nature and were excluded from analysis. Of the 20 patients with recurrent endometrial cancer who underwent exenteration with curative intent, all had previously received pelvic radiotherapy, 14 as part of their primary treatment and 6 as part of the treatment of recurrent disease. Six of 20 patients also received chemotherapy or hormonal therapy prior to exenteration. The median patient age was 65 years (range 44-79 years). At most recent follow-up, 8 patients were alive and disease free, 2 were alive with disease, 6 had died of disease, and 4 had died of other causes. The median follow-up of living patients is 89 months. Twelve of 20 patients experienced major complications, the most common of which was neovaginal flap necrosis. Of the 20 patients, 1 patient (5%) died in 1963 of surgical complications. The Kaplan-Meier estimate of 5-year disease-free survival is 45%. Pelvic exenteration can produce an acceptable rate of disease-free survival in highly selected patients with local recurrence of endometrial adenocarcinoma who have exhausted other treatment modalities.
- Subjects :
- Adult
medicine.medical_specialty
medicine.medical_treatment
Adenocarcinoma
Endometrium
Disease-Free Survival
medicine
Carcinoma
Humans
Survival rate
Aged
Retrospective Studies
Chemotherapy
Pelvic exenteration
business.industry
Obstetrics and Gynecology
Retrospective cohort study
Middle Aged
medicine.disease
Endometrial Neoplasms
Pelvic Exenteration
Surgery
Survival Rate
medicine.anatomical_structure
Oncology
Lymphatic Metastasis
Hormonal therapy
Female
Neoplasm Recurrence, Local
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....986f006e7e826e603759bc2855edbc55