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Tilt-induced clustering of cell adhesion proteins
- Publication Year :
- 2023
-
Abstract
- Cell adhesion proteins are transmembrane proteins that bind cells to their environment. These proteins typically cluster into disk-shaped or linear structures. Here we show that such clustering patterns spontaneously emerge when the protein sense the membrane deformation gradient, for example by reaching a lower-energy conformation when the membrane is tilted relative to the underlying binding substrate. Increasing the strength of the membrane gradient-sensing mechanism first yields isolated disk-shaped clusters and then long linear structures. Our theory is coherent with experimental estimates, suggesting that a tilt-induced clustering mechanism is relevant in the context of cell adhesion proteins.<br />6 pages, 3 figures, with SI (ancillary files)
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....987b806133a59b633c71c2c74832dcab