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Adaptation of Mycoplasmas to Antimicrobial Agents: Acholeplasma laidlawii Extracellular Vesicles Mediate the Export of Ciprofloxacin and a Mutant Gene Related to the Antibiotic Target
- Source :
- The Scientific World Journal, The Scientific World Journal, Vol 2014 (2014)
- Publication Year :
- 2014
- Publisher :
- Hindawi Publishing Corporation, 2014.
-
Abstract
- This study demonstrated that extracellular membrane vesicles are involved with the development of resistance to fluoroquinolones by mycoplasmas (class Mollicutes). This study assessed the differences in susceptibility to ciprofloxacin among strains ofAcholeplasma laidlawiiPG8. The mechanisms of mycoplasma resistance to antibiotics may be associated with a mutation in a gene related to the target of quinolones, which could modulate the vesiculation level.A. laidlawiiextracellular vesicles mediated the export of the nucleotide sequences of the antibiotic target gene as well as the traffic of ciprofloxacin. These results may facilitate the development of effective approaches to control mycoplasma infections, as well as the contamination of cell cultures and vaccine preparations.
- Subjects :
- DNA Topoisomerase IV
DNA, Bacterial
Article Subject
medicine.drug_class
Antibiotics
Molecular Sequence Data
lcsh:Medicine
Microbial Sensitivity Tests
Biology
medicine.disease_cause
Microscopy, Atomic Force
lcsh:Technology
General Biochemistry, Genetics and Molecular Biology
Microbiology
Microscopy, Electron, Transmission
Ciprofloxacin
Sequence Homology, Nucleic Acid
Extracellular
medicine
Amino Acid Sequence
Acholeplasma laidlawii
lcsh:Science
Gene
General Environmental Science
Mutation
Base Sequence
Sequence Homology, Amino Acid
lcsh:T
lcsh:R
Biological Transport
General Medicine
Mycoplasma
Antimicrobial
Adaptation, Physiological
Anti-Bacterial Agents
Cell culture
Genes, Bacterial
lcsh:Q
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23566140
- Database :
- OpenAIRE
- Journal :
- The Scientific World Journal
- Accession number :
- edsair.doi.dedup.....987d0728d0c8afad8e22f5cfdb7322a6
- Full Text :
- https://doi.org/10.1155/2014/150615