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Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice
- Source :
- Europe PubMed Central
- Publication Year :
- 1995
-
Abstract
- C/EBP beta is considered a key element of interleukin-6 (IL-6) signalling as well as an important transcriptional regulator of the IL-6 gene itself. We describe here how mice lacking C/EBP beta develop a pathology similar to mice overexpressing IL-6 and nearly identical to multicentric Castleman's disease in human patients, with marked splenomegaly, peripheral lymphadenopathy and enhanced haemopoiesis. Humoral, innate and cellular immunity are also profoundly distorted, as shown by the defective activation of splenic macrophages, the strong impairement of IL-12 production, the increased susceptibility to Candida albicans infection and the altered T-helper function. Our data show that C/EBP beta is crucial for the correct functional regulation and homeostatic control of haemopoietic and lymphoid compartments.
- Subjects :
- CD4-Positive T-Lymphocytes
Male
Cellular immunity
Lymphoproliferative disorders
Spleen
Nitric Oxide
General Biochemistry, Genetics and Molecular Biology
gene targeting
Mice
T-helper
medicine
Animals
Humans
Beta (finance)
Interleukin 6
Molecular Biology
Antibodies, Fungal
IL-6
Myeloproliferative Disorders
General Immunology and Microbiology
biology
Ccaat-enhancer-binding proteins
Interleukin-6
General Neuroscience
Castleman Disease
Candidiasis
Gene targeting
Nuclear Proteins
Castelman's disease
C/EBP
Macrophage Activation
medicine.disease
Lymphoproliferative Disorders
Mice, Mutant Strains
DNA-Binding Proteins
Disease Models, Animal
medicine.anatomical_structure
Immunology
biology.protein
CCAAT-Enhancer-Binding Proteins
Female
Lymph Nodes
Antibody
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....9883d61881eb7879ed78205cd6067ff3