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Failure of Classical β-Blocker Carvedilol to Deactivate Brown Adipose Tissue in a Patient With Pheochromocytoma
- Source :
- Clinical nuclear medicine. 43(8)
- Publication Year :
- 2018
-
Abstract
- A 37-year-old woman with pheochromocytoma underwent presurgical FDG PET/CT. Despite her usual antiadrenergic medication consisting in 25 mg of carvedilol, PET/CT demonstrated intense and widespread FDG uptake in brown adipose tissue (BAT). No BAT FDG uptake was detectable on a repeated examination after specific preparation consisting in 40 mg propranolol and 5 mg diazepam. We therefore recommend this propranolol-diazepam preparation in patients with pheochromocytoma referred for PET/CT. Carvedilol-classically prescribed to alleviate effects of adrenergic overstimulation-seems ineffective on BAT. This observation questions the benefit of carvedilol to reduce β3-adrenoreceptor-mediated effects, not only in BAT, but also in other tissues.
- Subjects :
- Adult
medicine.medical_specialty
Adrenergic beta-Antagonists
Urology
Adrenal Gland Neoplasms
Carbazoles
Adrenergic
Adipose tissue
Propranolol
Pheochromocytoma
030218 nuclear medicine & medical imaging
Propanolamines
03 medical and health sciences
0302 clinical medicine
Adipose Tissue, Brown
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Brown adipose tissue
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Treatment Failure
Carvedilol
business.industry
Fdg uptake
General Medicine
medicine.disease
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
business
Diazepam
medicine.drug
Subjects
Details
- ISSN :
- 15360229
- Volume :
- 43
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Clinical nuclear medicine
- Accession number :
- edsair.doi.dedup.....9891d26914125de751f24f9bb68d7eb9